Amylase Inhibitors
Also indexed as: Phaseolamin, Starch Blockers, Wheat Amylase Inhibitor, White Kidney Bean Extract
Amylase inhibitors are also known as starch blockers because they contain substances that prevent dietary starches from being absorbed by the body. Starches are complex carbohydrates that cannot be absorbed unless they are first broken down by the digestive enzyme amylase and other, secondary, enzymes.1 2 They are claimed to be useful for weight loss, but when they were first developed years ago, research did not find them very effective for limiting carbohydrate absorption.3 4 5 6 Later, however, highly concentrated versions of amylase inhibitors did show potential for reducing carbohydrate absorption in humans.7 8 9
Where are they found?
Amylase inhibitors can be extracted from several types of plants, especially those in the legume family. Currently available Amylase inhibitors are extracted from either white kidney bean or wheat.
Amylase inhibitors have been used in connection with the following conditions (refer to the individual health concern for complete information):
| Science Ratings | Health Concerns |
|---|---|
 |
Type 1 diabetes Type 2 diabetes Weight loss and obesity |
 Reliable
and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies
suggesting a health benefit or minimal health benefit. For an herb, supported by traditional use but minimal
or no scientific evidence. For a supplement, little scientific support and/or minimal health
benefit. |
|
Who is likely to be deficient?
Amylase inhibitors are not essential nutrients and are not normally produced in the body, so no deficiency is possible.
How much is usually taken?
Depending on the potency of the amylase inhibitors , typical intake is 1,500 to 6,000 mg before meals.
Are there any side effects or interactions?
High amounts of amylase inhibitors may cause diarrhea due to the effects of undigested starch in the colon.10 11 Diabetics taking medications to lower their blood sugar should not take amylase inhibitors without first consulting a doctor.
At the time of writing, there were no well-known drug interactions with amylase inhibitors.
References
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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires September 2008.